Unapposed hemichannels formed by oligomerized hexamers of gap junction proteins are now known to be involved in various cellular processes Machines under both physiological and pathological conditions.On the other hand, less is known regarding how disparities in the molecular composition of hemichannels impact electrical synaptic transmission betwe
FOXC2, a member of the forkhead box family of transcription factors, is an emerging oncogene that has read more been linked to several hallmarks of cancer progression.Among its many oncogenic functions is the promotion of drug resistance, with evidence supporting roles for FOXC2 in escape from broad classes of chemotherapeutics across an array of c
Esse estudo analisa as configurações da Gestão de Recursos Humanos das empresas portuguesas e brasileiras no que concerne aos negócios internacionais visto a importância de entender essa área frente às mudanças do contexto global.Para tanto, foi realizado um estudo de caso qualitativo em uma multinacional brasileira e em uma portuguesa por
Background: The glucocorticoid receptor (GR) is frequently expressed in breast cancer (BC), and its prognostic implications are contingent on estrogen receptor (ER) status.To address conflicting reports and explore therapeutic potential, a GR signature (GRsig) independent of ER status was developed.We also investigated cell type-specific GR protein